Endocrinology and genomics
- Director
- Jacques Simard
- Address
- 2705, boulevard Laurier, T-3-67
Québec (Québec)
CANADA G1V 4G2 - Phone
- +1 418-654-2296
- Fax
- +1 418-654-2298
No active offer
All active job offersNo active study
All active clinical studiesThe endocrinology and genomics group studies hormonal mechanisms and endocrine disorders associated with steroids and neuropeptides. As hormones modulate gene expression in target tissues, genomics was a natural addition over the years to the research program in this area. The group focuses particular attention on identifying and evaluating the contribution of genetic determinants to complex diseases. The main topics studied in this cutting-edge sector include biosynthesis, inactivation, description and control of hormone action, and genetic aspects of hormonal diseases. Researchers draw on an array of technologies including cellular and molecular biology, gene expression, genomics, proteomics, medicinal chemistry, protein crystallography, mass spectrometry, genetically-modified mice, and bioinformatics.
Researchers
Active research projects (see all research project in this area)
Characterizing the transcriptional regulation of the metastasis suppressor gene Growth Arrest Specific 1 (Gas1) in metastatic melanoma
Stéphane Gobeil
Stéphane Gobeil
UNDERSTANDING THE FUNCTION OF THE NEW METASTASIS SUPPRESSOR GENE GROWTH ARREST SPECIFIC 1 (GAS1)
Stéphane Gobeil
Stéphane Gobeil
Réseau de Médecine Génétique et Appliquée du Fonds de la recherche en santé du Québec (FRSQ) - Regroupement stratégique : « Next Generation Integrative Genomics (RS3) » du RMGA
Jacques Simard
Jacques Simard
CIHR Team in familial risks of breast cancer
Jacques Simard
Jacques Simard
Thème 3: Cancer de la prostate
Olivier Barbier, Alain Bélanger, Bernard Têtu
Olivier Barbier, Alain Bélanger, Bernard Têtu
Theme 1 : Glucuronidation et maladies cardiovasculaires
Olivier Barbier
Olivier Barbier
Theme 2 : Glucuronidation et maladies hépatiques
Olivier Barbier
Olivier Barbier
Pharmacogénomique et transplantation de cellules hématopoiëtiques (IRSC - Eric Lévesque, MD/Ph.D.)
Chantal Guillemette
Chantal Guillemette
Modulation de la voie de glucuronidation (IRSC)
Chantal Guillemette
Chantal Guillemette
Profil métabolique des estrogènes chez la femme (IRSC)
Chantal Guillemette
Chantal Guillemette
Recent publications (see all publications in this area)
Turcot V, Bouchard L, Faucher G, Garneau V, Tchernof A, Deshaies Y, Perusse L, Marceau S, Biron S, Lescelleur O, Biertho L, Vohl MC. Thymic stromal lymphopoietin: an immune cytokine gene associated with the metabolic syndrome and blood pressure in severe obesity. Clinical science (London, England : 1979)
,
2012. 123: 271
Cloutier N, Pare A, Farndale RW, Schumacher HR, Nigrovic PA, Lacroix S, Boilard E. Platelets can enhance vascular permeability. Blood,
2012. Epub
Rudkowska I, Jacques H, Weisnagel SJ, Marette A, Vohl MC. Transcriptomic profiles of skeletal muscle tissue following an euglycemic-hyperinsulinemic clamp in insulin-resistant obese subjects. Genes & nutrition,
2012. Epub
Ramus SJ, Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Sinilnikova OM, Healey S, Barrowdale D, Lee A, Thomassen M, Gerdes AM, Kruse TA, Jensen UB, Skytte AB, Caligo MA, Liljegren A, Lindblom A, Olsson H, Kristoffersson U, Stenmark-Askmalm M, Melin B, SWE-BRCA, Domchek SM, Nathanson KL, Rebbeck TR, Jakubowska A, Lubinski J, Jaworska K, Durda K, Zlowocka E, Gronwald J, Huzarski T, Byrski T, Cybulski C, Toloczko-Grabarek A, Osorio A, Benitez J, Duran M, Tejada MI, Hamann U, Rookus M, van Leeuwen FE, Aalfs CM, Meijers-Heijboer HE, van Asperen CJ, van Roozendaal KE, Hoogerbrugge N, Collee JM, Kriege M, van der Luijt RB, HEBON, EMBRACE, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Jacobs C, Eeles R, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Paterson J, Douglas F, Brewer C, Hodgson S, Morrison PJ, Walker L, Porteous ME, Kennedy MJ, Pathak H, Godwin AK, Stoppa-Lyonnet D, Caux-Moncoutier V, de Pauw A, Gauthier-Villars M, Mazoyer S, Leone M, Calender A, Lasset C, Bonadona V, Hardouin A, Berthet P, Bignon YJ, Uhrhammer N, Faivre L, Loustalot C, GEMO, Buys S, Daly M, Miron A, Terry MB, Chung WK, John EM, Southey M, Goldgar D, Singer CF, Tea MK, Pfeiler G, Fink-Retter A, Hansen Tv, Ejlertsen B, Johannsson OT, Offit K, Kirchhoff T, Gaudet MM, Vijai J, Robson M, Piedmonte M, Phillips KA, Van Le L, Hoffman JS, Ewart Toland A, Montagna M, Tognazzo S, Imyanitov E, Issacs C, Janavicius R, Lazaro C, Blanco I, Tornero E, Navarro M, Moysich KB, Karlan BY, Gross J, Olah E, Vaszko T, Teo SH, Ganz PA, Beattie MS, Dorfling CM, van Rensburg EJ, Diez O, Kwong A, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Heidemann S, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Fiebig B, Schafer D, Caldes T, de la Hoya M, Nevanlinna H, Aittomaki K, Plante M, Spurdle AB, kConFab, Neuhausen SL, Ding YC, Wang X, Lindor N, Fredericksen Z, Pankratz VS, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Bonanni B, Bernard L, Dolcetti R, Papi L, Ottini L, Radice P, Greene MH, Mai PL, Andrulis IL, Glendon G, Ozcelik H, OCGN, Pharoah PD, Gayther SA, Simard J, Easton DF, Couch FJ, Chenevix-Trench G, Consortium of Investigators of Modifiers of BRCA1/2. Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Human mutation,
2012. 33: 690-702
Do Rego JL, Seong JY, Burel D, Leprince J, Vaudry D, Luu-The V, Tonon MC, Tsutsui K, Pelletier G, Vaudry H. Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides Frontiers in endocrinology,
2012. 3: Article 4:1-15
Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Ebeling PR, Daly RM. Low Serum 25-Hydroxyvitamin D Is Associated with Increased Risk of the Development of the Metabolic Syndrome at Five Years: Results from a National, Population-Based Prospective Study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). The Journal of clinical endocrinology and metabolism,
2012. Epub
Santiquet N, Vallieres L, Pothier F, Sirard MA, Robert C, Richard F. Transplanted bone marrow cells do not provide new oocytes but rescue fertility in female mice following treatment with chemotherapeutic agents. Cellular reprogramming,
2012. 14: 123-9
Lundgren JD, Drapeau V, Allison KC, Gallant A, Tremblay A, Lambert M, Lemieux S, O'Loughlin J, Perusse L, Stunkard AJ. Prevalence and Familial Patterns of Night Eating in the Quebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Study. Obesity (Silver Spring, Md.),
2012. Epub
Gauthier S, Martel C, Labrie F. Steroid derivatives as pure antagonists of the androgen receptor. The Journal of steroid biochemistry and molecular biology,
2012. Epub
Bouchard-Mercier A, Paradis AM, Perusse L, Vohl MC. Associations between Polymorphisms in Genes Involved in Fatty Acid Metabolism and Dietary Fat Intakes. Journal of nutrigenetics and nutrigenomics,
2012. Epub
